Fmoc-AEEA-AEEA

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Fmoc-AEEA-AEEA (CAS No. 560088-89-3, molecular formula C₂₇H₃₄N₂O₉) is a white solid compound used in peptide synthesis as a protected, extended spacer. Composed of two AEEA units and an Fmoc-protected amino group, it provides optimal flexibility and spacing in solid-phase peptide assembly. This structure is particularly valuable in the development of GLP-1 receptor agonists such as Semaglutide and Tirzepatide, where precise side chain architecture improves peptide behavior and therapeutic effect.

CAS No.: 560088-89-3
Molecular Formula: C₂₇H₃₄N₂O₉
Purity: 99% min

Appearance White solid
Molecular Weight 530.6 g/mol
Density 1.3 ± 0.1 g/cm³
Boiling Point 757.6 ± 70.0 °C at 760 mmHg
Melting Point N/A
Flash Point 412.0 ± 35.7 °C
Packaging 25 kg/fibre drum
Storage Conditions Store at 2–8 °C
Monthly Production Capacity 300 kg/month

Product Name
1. Fmoc-AEEA-AEEA-OH;
2. Fmoc-AEEA-AEEA;
3. Fmoc-o2oc-o2oc-oh;
4. 1-(9H-Fluoren-9-yl)-3,12-dioxo-2,7,10,16,19-pentaoxa-4,13-diazahenicosan-21-oic acid;
5. 2-[2-[2-[[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetic acid
Applications Side chain intermediate for Semaglutide and Tirzepatide synthesis

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